Lesson on Vitamin B12 Deficiency Symptoms including Depression, Fatigue and Irreversible neurological issues (ex. proprioception, paresthesia) along with why these symptoms happen (pathogenesis), how to diagnose Vitamin B12 deficiency (ex. Schilling’s test), and how to treat this condition. Vitamin B12 (cobalamin) is obtained from our diet and is required for production and health of red blood cells and health and function of the central nervous system. Vitamin B12 deficiency can be due to reduced dietary intake, and a variety of processes and conditions that compromise absorption. Vitamin B12 deficiency leads to particular reversible and irreversible neurological symptoms along with symptoms of anemia (due to megaloblastic, macrocytic anemia). The diagnosis of B12 involves laboratory investigations along with the Schilling’s Test. Treatment depends on whether B12 deficiency is due to nutritional or issues with absorption.
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